By Madison Park, CNN

Despite two injections of anesthetic, Amy Anderson felt like her dentist was jamming rods into her tooth during a root canal. She writhed in pain as her infected tooth was hollowed with a drill, its nerve amputated, and then sealed.

“I knew this time something was wrong. I could feel my lips,” said the Syracuse, New York, resident, who told her dentist the drugs weren’t working.

Her doctor kept assuring her she had given her a proper dose and said: “I’m almost done.”

“I was hurting so bad, I was hitting myself in the stomach,” said Anderson, a redhead. “I almost wanted to hit her.”

Studies have indicated that redheads may be more sensitive to pain and may need more anesthetics to numb them.

New research published in this month’s Journal of American Dental Association found that painful experiences at the dentist might cause more anxiety for men and women with red hair, who were twice as likely to avoid dental care than people with dark hair. 

“Redheads are sensitive to pain,” said Dr. Daniel Sessler, an Outcomes Research Department chair at The Cleveland Clinic, in Cleveland, Ohio, who is one of the authors.

“They require more generalized anesthesia, localized anesthesia. The conventional doses fail. They have bad experiences at the dentist and because of the bad experiences, they could avoid dental care.”

Sessler, an anesthesiologist, began studying redheads’ sensitivity to pain after hearing chatter from colleagues.

“The persistent rumor in the anesthesia community was that redheads were difficult to anesthetize,” Sessler said. “They didn’t go under, had a lot of pain, didn’t respond well to anesthesia. Urban legends usually don’t start studies, but it was such an intriguing observation.”

This led to two studies. In 2004, research showed that people with red hair need 20 percent more general anesthesia than blonds and brunettes.

A 2005 study indicated that redheads are more sensitive to thermal pain and are more resistant to the effects of local anesthesia.

Researchers believe variants of the melanocortin-1 receptor gene play a role. This MC1R gene produces melanin, which gives skin, hair and eyes their color.

While blond, brown and black-haired people produce melanin, those with red hair have a mutation of this receptor. It produces a different coloring called pheomelanin, which results in freckles, fair skin and ginger hair. About 5 percent of whites are estimated to have these characteristics.

While the relationship between MC1R and pain sensitivity is not entirely understood, researchers have found MC1R receptors in the brain and some of them are known to influence pain sensitivity.

Non-redheads can also carry a variant of the MC1R gene. In this dental study that had 144 participants, about a quarter of the non-redheads had variants of the MC1R gene. These people also experienced heightened anxiety and avoided dental care compared with others who did not have the variant.

More here.

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